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Entry of chloride ions brings about an inhibitory opportunity that minimizes the power of neurons to depolarize to the edge potential necessary to make action potentials. Abnormal depolarization of neurons is implicated from the technology and spread of seizures. It truly is thought that diazepam enhances the actions of GABA by triggering GABA to bind additional tightly to the GABAA receptor
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Even though the specific mechanism by which diazepam exerts its antiseizure effects is unknown, animal As well as in vitro studies propose that diazepam functions to suppress seizures by means of an interaction with gamma-aminobutyric acid (GABA) receptors in the A-kind (GABAA). GABA, the foremost inhibitory neurotransmitter within the central anxious system, functions at this receptor to open up the membrane channel making it possible for chloride ions to circulation into neurons.